Carbonic anhydrase IX expression and outcome after radiotherapy for muscle-invasive bladder cancer

Sherwood, B. T., Colquhoun, A. J., Richardson, D., Bowman, K. J., O'Byrne, Kenneth J., Kockelbergh, R. C., Symonds, R. P., Mellon, J. K., & Jones, G. D. D. (2007) Carbonic anhydrase IX expression and outcome after radiotherapy for muscle-invasive bladder cancer. Clinical Oncology, 19(10), pp. 777-783.

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Abstract

Aims: Carbonic anhydrase IX (CA IX) expression has been described as an endogenous marker of hypoxia in solid neoplasms. Furthermore, CA IX expression has been associated with an aggressive phenotype and resistance to radiotherapy. We assessed the prognostic significance of CA IX expression in patients with muscle-invasive bladder cancer treated with radiotherapy.

Materials and methods: A standard immunohistochemistry technique was used to show CA IX expression in 110 muscle-invasive bladder tumours treated with radiotherapy. Clinicopathological data were obtained from medical case notes.

Results: CA IX immunostaining was detected in 89 (∼81%) patients. Staining was predominantly membranous, with areas of concurrent cytoplasmic and nuclear staining and was abundant in luminal and perinecrotic areas. No significant correlation was shown between the overall CA IX status and the initial response to radiotherapy, 5-year bladder cancer-specific survival or the time to local recurrence.

Conclusions: The distribution of CA IX expression in paraffin-embedded tissue sections seen in this series is consistent with previous studies in bladder cancer, but does not provide significant prognostic information with respect to the response to radiotherapy at 3 months and disease-specific survival after radical radiotherapy. © 2007 The Royal College of Radiologists.

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ID Code: 65689
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Bladder cancer, carbonic anhydrase IX, hypoxia, radiotherapy, carbonate dehydratase IX, paraffin, adult, aged, article, bladder muscle, cancer invasion, cancer radiotherapy, cancer recurrence, cancer survival, controlled study, correlation analysis, cytoplasm, female, human, human tissue, immunohistochemistry, major clinical study, male, medical record, priority journal, prognosis, protein expression, transurethral resection, treatment outcome, treatment response, Aged, 80 and over, Antigens, Neoplasm, Carbonic Anhydrases, Disease-Free Survival, Gene Expression Profiling, Humans, Middle Aged, Neoplasm Recurrence, Local, Urinary Bladder Neoplasms
DOI: 10.1016/j.clon.2007.06.014
ISSN: 0936-6555
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 W.B. Saunders Co. Ltd.
Deposited On: 06 Jan 2014 05:47
Last Modified: 11 Mar 2014 05:19

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