Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis

Sutton, Christopher D., O'Byrne, Kenneth J., Goddard, Jonathan C., Marshall, Leslie-Jayne, Jones, Louise, Garcea, Guiseppe, Dennison, Ashley R., Poston, Graham, Lloyd, David M., & Berry, David P. (2005) Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis. Clinical Cancer Research, 11(18), pp. 6567-6573.

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Purpose The aim of this study was to examine the expression and prognostic relevance of thrombospondin-1 (TSP-1) in tumor biopsies taken from a consecutive series of liver resections done at the University Hospitals of Leicester and the Royal Liverpool Hospital.

Experimental Design Patients having undergone a liver resection for colorectal liver metastases at our institutions between 1993 and 1999 inclusive were eligible. Inclusion criteria were curative intent, sufficient tumor biopsy, and patient follow-up data. One hundred eighty-two patients were considered in this study. Standard immunohistochemical techniques were used to study the expression of TSP-1 in 5-μm tumor sections from paraffin-embedded tissue blocks. TSP-1 was correlated with survival using the Kaplan-Meier method and log-rank test for univariate analysis and the Cox proportional hazard model for multivariate analysis.

Results One hundred eighty-two patients (male, n = 122 and female, n = 60) ages between 25 and 81 years (mean, 61 years) were included. TSP-1 was expressed around blood vessels (n = 45, 25%) or in the stroma (n = 59, 33%). No expression was detected in the remaining tumors. TSP-1 significantly correlated with poor survival on univariate (P = 0.01 for perivascular expression and P = 0.03 for stromal expression) and multivariate analysis (P = 0.01 for perivascular expression).

Conclusion TSP-1 is a negatively prognostic factor for survival in resected colorectal liver metastases. © 2005 American Association for Cancer Research.

Impact and interest:

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ID Code: 65718
Item Type: Journal Article
Refereed: Yes
Additional Information: Articles free to read on journal website after 12 months
Additional URLs:
Keywords: thrombospondin 1, adult, aged, article, colorectal carcinoma, correlation analysis, female, follow up, human, immunohistochemistry, liver metastasis, liver resection, major clinical study, male, multivariate analysis, prediction, priority journal, prognosis, protein expression, statistical significance, tumor biopsy, Aged, 80 and over, Colorectal Neoplasms, Humans, Liver Neoplasms, Middle Aged, Predictive Value of Tests, Survival Analysis
DOI: 10.1158/1078-0432.CCR-05-0439
ISSN: 1078-0432
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2005 American Association for Cancer Research
Deposited On: 07 Jan 2014 06:40
Last Modified: 29 Jan 2015 05:21

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