Computational simulation of the early stage of bone healing under different configurations of locking compression plates
Miramini, Saeed, Zhang, Lihai, Richardson, Martin, Pirpiris, Marinis, Mendis, Priyan, Oloyede, Kunle, & Edwards, Glenn (2015) Computational simulation of the early stage of bone healing under different configurations of locking compression plates. Computer Methods in Biomechanics and Biomedical Engineering, 18(8), pp. 900-913.
Flexible fixation or the so-called ‘biological fixation’ has been shown to encourage the formation of fracture callus, leading to better healing outcomes. However, the nature of the relationship between the degree of mechanical stability provided by a flexible fixation and the optimal healing outcomes has not been fully understood. In this study, we have developed a validated quantitative model to predict how cells in fracture callus might respond to change in their mechanical microenvironment due to different configurations of locking compression plate (LCP) in clinical practice, particularly in the early stage of healing. The model predicts that increasing flexibility of the LCP by changing the bone–plate distance (BPD) or the plate working length (WL) could enhance interfragmentary strain in the presence of a relatively large gap size (.3 mm). Furthermore, conventional LCP normally results in asymmetric tissue development during early stage of callus formation, and the increase of BPD or WL is insufficient to alleviate this problem.
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|Item Type:||Journal Article|
|Keywords:||bone healing, computational modelling, locking compression plate, interfragmentary strain, tissue differentiation|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2015 Taylor & Francis|
|Deposited On:||07 Jan 2014 23:10|
|Last Modified:||17 Dec 2014 07:45|
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