Porohyperelastic analysis of single osteocyte using AFM and inverse FEA

Nguyen, Trung Dung, Oloyede, Adekunle, Singh, Sanjleena, & Gu, YuanTong (2014) Porohyperelastic analysis of single osteocyte using AFM and inverse FEA. In Goh, James (Ed.) IFMBE Proceedings : The 15th International Conference on Biomedical Engineering, Springer International Publishing, Singapore, pp. 56-59.

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Osteocytes are the mature cells and perform as mechanosensors within the bone. The mechanical property of osteocytes plays an important role to fulfill these functions. However, little researches have been done to investigate the mechanical deformation properties of single osteocytes. Atomic Force Microscopy (AFM) is a state-of-art experimental facility for high resolution imaging of tissues, cells and any surfaces as well as for probing mechanical properties of the samples both qualitatively and quantitatively. In this paper, the experimental study based on AFM is firstly used to obtain forceindentation curves of single round osteocytes. The porohyperelastic (PHE) model of a single osteocyte is then developed by using the inverse finite element analysis (FEA) to identify and extract mechanical properties from the experiment results. It has been found that the PHE model is a good candidature for biomechanics studies of osteocytes.

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ID Code: 65802
Item Type: Conference Paper
Refereed: Yes
Additional URLs:
Keywords: Biomechanics, Osteocytes, Finite Element Analysis, Porohyperelastic, AFM
DOI: 10.1007/978-3-319-02913-9_15
ISBN: 9783319029122
ISSN: 1680-0737
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > NUMERICAL AND COMPUTATIONAL MATHEMATICS (010300) > Numerical Analysis (010301)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Biochemistry and Cell Biology not elsewhere classified (060199)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 09 Jan 2014 00:03
Last Modified: 07 Apr 2014 02:17

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