Porohyperelastic analysis of single chondrocyte using AFM and inverse FEA

Nguyen, Trung Dung & Gu, YuanTong (2013) Porohyperelastic analysis of single chondrocyte using AFM and inverse FEA. In 5th Asia Pacific Congress on Computational Mechanics & 4th International Symposium on Computational Mechanics, 11-14 December 2013, Singapore.

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The aim of this paper is to determine the creep and relaxation responses of single chondrocytes in vitro. Firstly, Atomic Force Microscopy (AFM) was used to obtain the force-indentation curves of single chondrocytes at the strain-rate of 7.05 s-1. This result was then employed in inverse finite element analysis (FEA) using porohyperelastic (PHE) idealization of the cells to determine their mechanical properties. The PHE model results agreed well with AFM experimental data. This PHE model was then utilized to study chondrocyte’s creep and relaxation behaviors. The results revealed that the effect of fluid was predominant for cell’s mechanical behaviors and that the PHE is a good model for biomechanics studies of chondrocytes.

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ID Code: 65806
Item Type: Conference Paper
Refereed: Yes
Additional URLs:
Keywords: Biomechanics, Chondrocytes, Finite Element Analysis, Porohyperelastic, AFM
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > NUMERICAL AND COMPUTATIONAL MATHEMATICS (010300) > Numerical Analysis (010301)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Biochemistry and Cell Biology not elsewhere classified (060199)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 Please consult the authors
Deposited On: 09 Jan 2014 00:22
Last Modified: 15 Jan 2014 03:45

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