Gene silencing as an adaptive defence against viruses

Waterhouse, P. M., Wang, M. B., & Lough, T. (2001) Gene silencing as an adaptive defence against viruses. Nature, 411(6839), pp. 834-842.

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Abstract

Gene silencing was perceived initially as an unpredictable and inconvenient side effect of introducing transgenes into plants. It now seems that it is the consequence of accidentally triggering the plant's adaptive defence mechanism against viruses and transposable elements. This recently discovered mechanism, although mechanistically different, has a number of parallels with the immune system of mammals.

Impact and interest:

674 citations in Scopus
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611 citations in Web of Science®

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ID Code: 65832
Item Type: Journal Article
Refereed: Yes
Keywords: adaptation, gene silencing, immune system, infection resistance, nonhuman, plant, priority journal, review, RNA degradation, transgene, transposon, virus infection, Animals, DNA Transposable Elements, Gene Expression Regulation, Plant, Methylation, Plant Diseases, Plant Viruses, Plants, Ribonucleases, RNA, Antisense, RNA, Small Interfering, RNA, Viral, Mammalia
DOI: 10.1038/35081168
ISSN: 0028-0836
Divisions: Current > Schools > School of Earth, Environmental & Biological Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Nature Publishing Group
Deposited On: 08 Jan 2014 04:34
Last Modified: 08 Jan 2014 04:34

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