Small RNA viruses of insects : expression in plants and RNA silencing

Gordon, Karl H.J. & Waterhouse, Peter M. (2006) Small RNA viruses of insects : expression in plants and RNA silencing. Advances in Virus Research : Insect Viruses : Biotechnological Applications, 68, pp. 459-502.

View at publisher


Interest in insect small RNA viruses (SRVs) has grown slowly but steadily. A number of new viruses have been analyzed at the sequence level, adding to our knowledge of their diversity at the level of both individual virus species and families. In particular, a number of possible new virus families have emerged. This research has largely been driven by interest in their potential for pest control, as well as in their importance as the causal agents of disease in beneficial arthropods. At the same time, research into known viruses has made valuable contributions to our understanding of an emerging new field of central importance to molecular biology-the existence of RNA-based gene silencing, developmental control, and adaptive immune systems in eukaryotes. Subject to RNA-based adaptive immune responses in their hosts, viruses have evolved a variety of genes encoding proteins capable of suppressing the immune response. Such genes were first identified in plant viruses, but the first examples known from animal viruses were identified in insect RNA viruses. This chapter will address the diversity of insect SRVs, and attempts to harness their simplicity in the engineering of transgenic plants expressing viruses for resistance to insect pests. We also describe RNA interference and antiviral pathways identified in plants and animals, how they have led viruses to evolve genes capable of suppressing such adaptive immunity, and the problems presented by these pathways for the strategy of expressing viruses in transgenic plants. Approaches for countering these problems are also discussed. © 2006 Elsevier Inc. All rights reserved.

Impact and interest:

19 citations in Scopus
Search Google Scholar™
20 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 65847
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: animal, biological pest control, genetics, insect control, insect virus, Lepidoptera, metabolism, phylogeny, plant, review, RNA interference, RNA virus, transgene, transgenic plant, virology, virus assembly, virus capsid, Animals, Capsid, Insect Viruses, Pest Control, Biological, Plants, Plants, Genetically Modified, RNA Viruses, Transgenes
DOI: 10.1016/S0065-3527(06)68013-5
ISSN: 1557-8399
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > PLANT BIOLOGY (060700)
Divisions: Current > Schools > School of Earth, Environmental & Biological Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2006 Elsevier
Deposited On: 09 Jan 2014 07:55
Last Modified: 05 Mar 2014 03:58

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page