The roles of plant dsRNA-binding proteins in RNAi-like pathways
Curtin, Shaun J., Watson, John M., Smith, Neil A., Eamens, Andrew L., Blanchard, Chris L., & Waterhouse, Peter M. (2008) The roles of plant dsRNA-binding proteins in RNAi-like pathways. FEBS Letters, 582(18), pp. 2753-2760.
Dicers are associated with double-stranded RNA-binding proteins (dsRBPs) in animals. In the plant, Arabidopsis, there are four dicer-like (DCL) proteins and five potential dsRBPs. These DCLs act redundantly and hierarchically. However, we show there is little or no redundancy or hierarchy amongst the DRBs in their DCL interactions. DCL1 operates exclusively with DRB1 to produce micro (mi)RNAs, DCL4 operates exclusively with DRB4 to produce trans-acting (ta) siRNAs and 21nt siRNAs from viral RNA. DCL2 and DCL3 produce viral siRNAs without requiring assistance from any dsRBP. DRB2, DRB3 and DRB5 appear unnecessary for mi-, tasi-, viral si-, or heterochromatinising siRNA production but act redundantly in a developmental pathway. © 2008 Federation of European Biochemical Societies.
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|Item Type:||Journal Article|
|Keywords:||Double-stranded RNA, Gene silencing pathway, RNA binding protein, RNA interference, double stranded RNA, microRNA, small interfering RNA, virus RNA, Arabidopsis, article, heterochromatin, plant genetics, priority journal, protein binding, protein interaction, Arabidopsis Proteins, DNA Transposable Elements, MicroRNAs, Mutation, Nucleic Acid Conformation, Phenotype, Phylogeny, Ribonuclease III, RNA, Double-Stranded, RNA, Plant, RNA, Small Interfering, RNA, Viral, RNA-Binding Proteins, Animalia|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > PLANT BIOLOGY (060700)
|Divisions:||Current > Schools > School of Earth, Environmental & Biological Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2008 Elsevier BV|
|Deposited On:||09 Jan 2014 02:45|
|Last Modified:||09 Jan 2014 02:47|
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