Plant and animal microRNAs : similarities and differences
Millar, Anthony A. & Waterhouse, Peter M. (2005) Plant and animal microRNAs : similarities and differences. Functional and Integrative Genomics, 5(3), pp. 129-135.
Plant and animal microRNAs (miRNAs) are evolutionarily ancient small RNAs, ∼19-24 nucleotides in length, that are generated by cleavage from larger highly structured precursor molecules. In both plants and animals, miRNAs posttranscriptionally regulate gene expression through interactions with their target mRNAs, and these targets are often genes involved with regulating key developmental events. Despite these similarities, plant and animal miRNAs exert their control in fundamentally different ways. Generally, animal miRNAs repress gene expression by mediating translational attenuation through (multiple) miRNA-binding sites located within the 3′ untranslated region of the target gene. In contrast, almost all plant miRNAs regulate their targets by directing mRNA cleavage at single sites in the coding regions. These and other differences suggest that the two systems may have originated independently, possibly as a prerequisite to the development of complex body plans. © Springer-Verlag 2005.
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|Item Type:||Journal Article|
|Keywords:||messenger RNA, plant RNA, ribonuclease III, RNA, RNA precursor, 3' untranslated region, 5' untranslated region, animal genetics, binding site, biogenesis, comparative study, gene cluster, gene expression regulation, gene function, gene targeting, genetic code, genetic transcription, genetic variability, nonhuman, plant genetics, priority journal, review, RNA analysis, RNA binding, RNA cleavage, RNA synthesis, RNA translation, Animals, Arabidopsis, MicroRNAs, RNA, Plant, Animalia|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > PLANT BIOLOGY (060700)
|Divisions:||Current > Schools > School of Earth, Environmental & Biological Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2005 Springer|
|Deposited On:||09 Jan 2014 04:06|
|Last Modified:||30 Jan 2014 00:29|
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