Role of short RNAs in gene silencing

Waterhouse, Peter M., Wang, Ming-Bo, & Finnegan, E. Jean (2001) Role of short RNAs in gene silencing. Trends in Plant Science, 6(7), pp. 297-301.

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Recent research has revealed the existence of an elegant defence mechanism in plants and lower eukaryotes. The mechanism, known in plants as post-transcriptional gene silencing, works through sequence-specific degradation of RNA. It appears to be directed by double-stranded RNA, associated with the production of short 21-25 nt RNAs, and spread through the plant by a diffusible signal. The short RNAs are implicated as the guides for both a nuclease complex that degrades the mRNA and a methyltransferase complex that methylates the DNA of silenced genes. It has also been suggested that these short RNAs might be the mobile silencing signal, a suggestion that has been challenged recently.

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ID Code: 65977
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: cysteine proteinase, double stranded RNA, HC Pro protein, potyvirus, HC-Pro protein, potyvirus, methyltransferase, plant DNA, plant RNA, vegetable protein, virus protein, adaptation, comparative study, DNA methylation, gene, gene silencing, genetic transcription, genetics, metabolism, physiology, plant, plant virus, review, RNA processing, signal transduction, transgenic plant, Adaptation, Physiological, Cysteine Endopeptidases, DNA, Plant, Genes, Plant, Methyltransferases, Plant Proteins, Plant Viruses, Plants, Plants, Genetically Modified, RNA Processing, Post-Transcriptional, RNA, Double-Stranded, RNA, Plant, Transcription, Genetic, Viral Proteins
DOI: 10.1016/S1360-1385(01)01989-6
ISSN: 1360-1385
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > PLANT BIOLOGY (060700)
Divisions: Current > Schools > School of Earth, Environmental & Biological Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2001 Elsevier Ltd.
Deposited On: 09 Jan 2014 07:23
Last Modified: 09 Jan 2014 07:24

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