Virus resistance and gene silencing : killing the messenger

Waterhouse, Peter M., Smith, Neil A., & Wang, Ming-Bo (1999) Virus resistance and gene silencing : killing the messenger. Trends in Plant Science, 4(11), pp. 452-457.

View at publisher


On occasion, virus-derived transgenes in plants can be poorly expressed and yet provide excellent virus resistance, and transgene constructs designed to supplement the expression of endogenous genes can have the effect of co-suppressing themselves and the endogenous genes. These two phenomena appear to result from the same post-transcriptional silencing mechanism, which operates by targeted-RNA degradation. Recent research into RNA-mediated virus resistance and co-suppression has provided insights into the interactions between plant viruses and their hosts, and spawned several models to explain the phenomenon.

Impact and interest:

90 citations in Scopus
Search Google Scholar™
87 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 66002
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: disease resistance, gene targeting, transgene, virus infection
DOI: 10.1016/S1360-1385(99)01493-4
ISSN: 1360-1385
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > PLANT BIOLOGY (060700)
Divisions: Current > Schools > School of Earth, Environmental & Biological Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 1999 Elsevier Ltd. * Trends Journals
Deposited On: 13 Jan 2014 00:02
Last Modified: 13 Jan 2014 00:03

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page