Age-related trends in urinary excretion of bisphenol A in Australian children and adults : evidence from a pooled sample study using samples of convenience
Heffernan, Amy, Aylward, Lesa, Toms, Leisa-Maree L., Eaglesham, Geoff, Hobson, Peter, Sly, Peter, & Mueller, Jochen (2013) Age-related trends in urinary excretion of bisphenol A in Australian children and adults : evidence from a pooled sample study using samples of convenience. Journal of Toxicology and Environmental Health, Part A : Current Issues, 76(18), pp. 1039-1055.
Bisphenol A (BPA or 4,4’-(propane-2,2-diyl)diphenol) is a chemical intermediate in the production of polycarbonate and epoxy resins, and used in a wide range of applications. BPA has attracted significant attention in the past decade due to its frequency of detection in human populations worldwide, demonstrated animal toxicity and potential impact on human health, particularly during critical periods of development. The aim of this study was to perform a preliminary assessment of age-related trends in urinary concentration and to estimate daily excretion of BPA in Australian children (aged (>0 – <5 years) and adults (≥15 – <75 years). This was achieved using 79 samples pooled by age and gender, created from 868 individual samples of convenience collected as part of routine, community-based pathology testing. Total BPA was analyzed using online-SPE-LC-MS/MS and detected in all samples with a range of 0.65 – 265 ng/ml. No significant differences were observed between males and females. A urine flow model was constructed from published values and used to provide an estimate of daily excretion per unit bodyweight for each pooled sample. The daily excretion estimates ranged from 26.2 – 18200 ng/kg-d for children; and 20.1 – 165 ng/kg-d for adults. Urinary concentrations and estimated excretion rates were inversely associated with age, and estimated daily excretion rates in infants and young children were significantly higher than in adults (geometric mean: 107 and 47.0 ng/kg-d, respectively). Higher excretion of BPA in children may be explained by their higher food consumption relative to body weight compared to adults and adolescents, and may also reflect alternative exposure pathways and sources.
Keywords: bisphenol A, biomonitoring, children, urine flow, Australia
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|Item Type:||Journal Article|
|Keywords:||bisphenol A , biomonitoring, children, urine flow, Australia|
|Subjects:||Australian and New Zealand Standard Research Classification > ENVIRONMENTAL SCIENCES (050000) > OTHER ENVIRONMENTAL SCIENCES (059900) > Environmental Sciences not elsewhere classified (059999)|
|Divisions:||Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2013 Taylor and Francis|
|Copyright Statement:||This is an Author's Accepted Manuscript of an article published in Journal of Toxicology and Environmental Health, Part A : Current Issues, 2013 copyright Taylor & Francis, available online at: http://www.tandfonline.com/.|
|Deposited On:||16 Jan 2014 00:08|
|Last Modified:||06 Dec 2014 23:57|
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