Colloidal drug probe : method development and validation for adhesion force measurement using atomic force microscopy

Tuli, Rinku A., Ganakas, George, George, Graeme A., Dargaville, Tim R., & Islam, Nazrul (2013) Colloidal drug probe : method development and validation for adhesion force measurement using atomic force microscopy. In Chemeca 2013 : Challenging Tomorrow, Engineers Australia, Brisbane Convention & Exhibition Centre, Queensland, Australia.

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Abstract

This study demonstrates a novel technique of preparing drug colloid probes to determine the adhesion force between the drug salbutamol sulphate (SS) and the surfaces of polymer microparticles to be used as carriers for the dispersion of drug particles from a dry powder inhaler (DPI) formulation. Initially model silica probes of approximately 4 μm size, similar to a drug particle used in DPI formulations, were coated with a saturated SS solution with the aid of capillary forces acting between the silica probe and the drug solution. The developed method of ensuring a smooth and uniform layer of SS on the silica probe was validated using X-Ray Photoelectron Spectroscopy (XPS) and Scanning Electron Microscopy (SEM). Using the same technique, silica microspheres preattached on the AFM cantilever were coated with SS. The adhesion forces between the silica probe and drug coated silica (drug probe) and polymer surfaces (hydrophilic and hydrophobic) were determined. Our experimental results showed that the technique for preparing the drug probe was robust and can be used to determine the adhesion force between hydrophilic/hydrophobic drug probe and carrier surfaces to gain a better understanding on drug carrier adhesion forces in DPI formulations.

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ID Code: 66482
Item Type: Conference Paper
Refereed: Yes
Additional URLs:
Keywords: Atomic Force Microscopy, Adhesion Force, Coating, Silica probe, Validation
ISBN: 9781922107077
Subjects: Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000)
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > NANOTECHNOLOGY (100700) > Nanotechnology not elsewhere classified (100799)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 22 Jan 2014 01:55
Last Modified: 22 Jan 2014 01:55

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