The potential role of lycopene for the prevention and therapy of prostate cancer : from molecular mechanisms to clinical evidence

Holzapfel, Nina Pauline, Holzapfel, Boris Michael, Champ, Simon, Feldthusen, Jesper, Clements, Judith A., & Hutmacher, Dietmar Werner (2013) The potential role of lycopene for the prevention and therapy of prostate cancer : from molecular mechanisms to clinical evidence. International Journal of Molecular Sciences, 14(7), pp. 14620-14646.

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Abstract

Lycopene is a phytochemical that belongs to a group of pigments known as carotenoids. It is red, lipophilic and naturally occurring in many fruits and vegetables, with tomatoes and tomato-based products containing the highest concentrations of bioavailable lycopene. Several epidemiological studies have linked increased lycopene consumption with decreased prostate cancer risk. These findings are supported by in vitro and in vivo experiments showing that lycopene not only enhances the antioxidant response of prostate cells, but that it is even able to inhibit proliferation, induce apoptosis and decrease the metastatic capacity of prostate cancer cells. However, there is still no clearly proven clinical evidence supporting the use of lycopene in the prevention or treatment of prostate cancer, due to the only limited number of published randomized clinical trials and the varying quality of existing studies. The scope of this article is to discuss the potential impact of lycopene on prostate cancer by giving an overview about its molecular mechanisms and clinical effects. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

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ID Code: 66485
Item Type: Journal Article
Refereed: Yes
Keywords: lycopene, prostate cancer, disease prevention, treatment, molecular mechanisms, animal models
DOI: 10.3390/ijms140714620
ISSN: 1422-0067
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Divisions: Current > Schools > School of Biomedical Sciences
Current > Institutes > Institute of Health and Biomedical Innovation
Funding:
Copyright Owner: Copyright 2013 by the authors; licensee MDPI, Basel, Switzerland
Copyright Statement: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Deposited On: 21 Jan 2014 23:12
Last Modified: 02 Sep 2016 06:27

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