A pre-clinical functional assessment of an acellular scaffold intended for the treatment of hard-to-heal wounds

Shooter, Gary K., Croll, Tristan I., Cao, Yang, Van Lonkhuyzen, Derek R., Xie, Yan, Broadbent, James A., Stupar, Dario, Lynam, Emily, & Upton, Zee (2015) A pre-clinical functional assessment of an acellular scaffold intended for the treatment of hard-to-heal wounds. International Wound Journal, 12(2), pp. 160-168.

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Dermal wound healing is a biochemical and cellular process critical to life. While the majority of the population will only ever experience successful wound healing outcomes, some 1-3 % of those aged over 65 years will experience wound healing delay or perpetuation. These hard-to-heal wounds are comprised of degraded and dysfunctional extracellular matrix, yet the integrity of this structure is critical in the processes of normal wound healing. As such, extracellular matrix replacements have been devised that can replace dysfunctional extracellular matrix in hard-to-heal wounds with the aim of restoring normal wound healing processes. Here we evaluated a novel synthetic matrix protein for its ability to act as an acellular scaffold that can replace dysfunctional extracellular matrix. In this regard the synthetic protein demonstrated an ability to rapidly adsorb to the dermal surface, permit cell attachment and facilitate the cellular functions essential to wound healing. When applied to deep partial thickness wounds in a porcine animal model the matrix protein also demonstrated the ability to reduce wound duration. These data provide evidence that the synthetic matrix protein has the ability to function as an acellular scaffold for wound healing purposes.

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ID Code: 66524
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: acellular scaffold, extracellular matrix, hard to heal wounds
DOI: 10.1111/iwj.12073
ISSN: 1742-4801
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Blackwell Publishing
Deposited On: 22 Jan 2014 23:29
Last Modified: 05 May 2015 00:11

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