The adaptive metabolic response to exercise-induced weight loss influences both energy expenditure and energy intake

Hopkins, M., Gibbons, C., Caudwell, P., Hellström, P.M., Näslund, E., King, N.A., Finlayson, G., & Blundell, J.E. (2014) The adaptive metabolic response to exercise-induced weight loss influences both energy expenditure and energy intake. European Journal of Clinical Nutrition, 68, pp. 581-586.

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Abstract

BACKGROUND/OBJECTIVEs

A decline in resting energy expenditure (REE) beyond that predicted from changes in body composition has been noted following dietary-induced weight loss. However, it is unknown whether a compensatory downregulation in REE also accompanies exercise (EX)-induced weight loss, or whether this adaptive metabolic response influences energy intake (EI).

SUBJECTS/METHODS

Thirty overweight and obese women (body mass index (BMI)=30.6±3.6 kg/m2) completed 12 weeks of supervised aerobic EX. Body composition, metabolism, EI and metabolic-related hormones were measured at baseline, week 6 and post intervention. The metabolic adaptation (MA), that is, difference between predicted and measured REE was also calculated post intervention (MApost), with REE predicted using a regression equation generated in an independent sample of 66 overweight and obese women (BMI=31.0±3.9 kg/m2).

RESULTS

Although mean predicted and measured REE did not differ post intervention, 43% of participants experienced a greater-than-expected decline in REE (−102.9±77.5 kcal per day). MApost was associated with the change in leptin (r=0.47; P=0.04), and the change in resting fat (r=0.52; P=0.01) and carbohydrate oxidation (r=−0.44; P=0.02). Furthermore, MApost was also associated with the change in EI following EX (r=−0.44; P=0.01).

CONCLUSIONS

Marked variability existed in the adaptive metabolic response to EX. Importantly, those who experienced a downregulation in REE also experienced an upregulation in EI, indicating that the adaptive metabolic response to EX influences both physiological and behavioural components of energy balance.

Impact and interest:

9 citations in Scopus
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9 citations in Web of Science®

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ID Code: 66575
Item Type: Journal Article
Refereed: Yes
Keywords: exercise-induced weight loss; energy intake; resting energy expenditure; leptin
DOI: 10.1038/ejcn.2013.277
ISSN: 1476-5640
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2014 Macmillan Publishers Limited
Deposited On: 23 Jan 2014 00:04
Last Modified: 16 Sep 2014 05:24

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