RANKL expression in periodontal disease : where does RANKL come from?

Chen, Bin, Wu, Wenlei, Sun, Weibin, Zhang, Qian, Yan, Fuhua, & Xiao, Yin (2014) RANKL expression in periodontal disease : where does RANKL come from? BioMed Research International, 2014(731039).

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Abstract

Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development and osteoclast function. Therefore, RANKL plays a critical role in periodontal bone resorption. In this review, we have summarized the sources of RANKL in periodontal disease and explored which factors may regulate RANKL expression in this disease.

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5 citations in Web of Science®

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ID Code: 66705
Item Type: Journal Article
Refereed: Yes
Keywords: Receptor activator of nuclear factor-κB ligand (RANKL), Periodontal disease, Bone resorption
DOI: 10.1155/2014/731039
ISSN: 2314-6133
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > DENTISTRY (110500)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2014 Bin Chen et al.
Copyright Statement: This is an open access article distributed under theCreativeCommonsAttribution License,which
permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Deposited On: 05 Mar 2014 00:18
Last Modified: 17 Mar 2014 05:05

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