New approaches to making the microenvironment of the female reproductive tract hostile to HIV

Fahey, John V., Bodwell, Jack E., Hickey, Danica K., Ghosh, Mimi, Muia, Maria N., & Wira, Charles R. (2011) New approaches to making the microenvironment of the female reproductive tract hostile to HIV. American Journal of Reproductive Immunology, 65(3), pp. 334-343.

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Abstract

The studies presented in this review explore three distinct areas with potential for inhibiting HIV infection in women. Based on emerging information from the physiology, endocrinology and immunology of the female reproductive tract (FRT), we propose unique 'works in progress' for protecting women from HIV. Various aspects of FRT immunity are suppressed by estradiol during the menstrual cycle, making women more susceptible to HIV infection. By engineering commensal Lactobacillus to secrete the anti-HIV molecule Elafin as estradiol levels increase, women could be protected from HIV infection. Selective estrogen response modifiers enhance barrier integrity and enhance secretion of protective anti-HIV molecules. Finally, understanding the interactions and regulation of FRT endogenous antimicrobials, proteases, antiproteases, etc., all of which are under hormonal control, will open new avenues to therapeutic manipulation of the FRT mucosal microenvironment. By seeking new alternatives to preventing HIV infection in women, we may finally disrupt the HIV pandemic.

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ID Code: 66749
Item Type: Journal Article
Refereed: Yes
Additional Information: Special Issue: Sexual Transmission of HIV in the 21st Century
DOI: 10.1111/j.1600-0897.2010.00949.x
ISSN: 0271-7352
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2011 John Wiley & Sons A/S
Deposited On: 30 Jan 2014 00:23
Last Modified: 04 Feb 2014 03:05

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