Effectiveness of an acellular synthetic matrix in the treatment of hard-to-heal leg ulcers

Harding, Keith, Aldons, Pat, Edwards, Helen, Stacey, Michael, Finlayson, Kathleen, Gibb, Michelle, Jenkins, Liz, Shooter, Gary, Van Lonkhuyzen, Derek, Lynam, Emily, Heinrichs, Eva-Lisa, & Upton, Zee (2014) Effectiveness of an acellular synthetic matrix in the treatment of hard-to-heal leg ulcers. International Wound Journal, 11(2), pp. 129-137.

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Abstract

Hard-to-heal leg ulcers are a major cause of morbidity in the elderly population. Despite improvements in wound care, some wounds will not heal and they present a significant challenge for patients and health care providers. A multi-centre cohort study was conducted to evaluate the effectiveness and safety of a synthetic, extracellular matrix protein as an adjunct to standard care in the treatment of hard-to-heal venous or mixed leg ulcers. Primary effectiveness criteria were (i) reduction in wound size evaluated by percentage change in wound area and (ii) healing assessed by number of patients healed by end of the 12 week study. Pain reduction was assessed as a secondary effectiveness criteria using VAS. A total of 45 patients completed the study and no difference was observed between cohorts for treatment frequency. Healing was achieved in 35·6% and wound size decreased in 93·3% of patients. Median wound area percentage reduction was 70·8%. Over 50% of patients reported pain on first visit and 87·0% of these reported no pain at the end of the study. Median time to first reporting of no pain was 14 days after treatment initiation. The authors consider the extracellular synthetic matrix protein an effective and safe adjunct to standard care in the treatment of hard-to-heal leg ulcers.

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ID Code: 66775
Item Type: Journal Article
Refereed: Yes
Keywords: Biomimetic scaffold; ECM protein; ECM replacement; Hard-to-heal wounds; Vitronectin
DOI: 10.1111/iwj.12115
ISSN: 1742-481X
Divisions: Current > Schools > School of Biomedical Sciences
Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Nursing
Copyright Owner: Copyright 2013 The Authors. International Wound Journal © 2013 Medicalhelplines.com Inc and John Wiley & Sons Ltd
Deposited On: 31 Jan 2014 00:22
Last Modified: 06 May 2015 09:50

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