The human topoisomerase I damage response plays a role in apoptosis

Søe, Kent, Rockstroh, Anja, Schache, Peter, & Grosse, Frank (2004) The human topoisomerase I damage response plays a role in apoptosis. DNA Repair, 3(4), pp. 387-393.

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Abstract

Previous studies have shown that human topoisomerase I cleavage complexes form as a response to various DNA damages in vivo, the so called human topoisomerase I “damage response”. It was suggested that this damage response may play a role in DNA repair as well as in apoptosis, but only very few investigations have been done and the significance of the damage response still remains unclear. Here we demonstrate that human topoisomerase I cleavage complexes induced by high doses of UV irradiation are highly stable for up to 48 h. Furthermore, we show that human topoisomerase I cleavage complexes correlate with apoptosis. However, at low UV doses the cleavage complex level was very low and the complexes were repaired. Surprisingly, we found that high levels of stable cleavage complexes were not only found in UV-irradiated cells but also in untreated cells that underwent apoptosis. A possible role of human topoisomerase I in apoptosis is discussed.

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19 citations in Scopus
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19 citations in Web of Science®

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ID Code: 67095
Item Type: Journal Article
Refereed: Yes
Keywords: topoisomerase I, apoptosis, DNA damage, Repair
DOI: 10.1016/j.dnarep.2003.12.003
ISSN: 15687864
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 10 Feb 2014 00:15
Last Modified: 10 Feb 2014 00:15

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