Scrub typhus in mainland China, 2006–2012 : the need for targeted public health interventions

Zhang, Wen-Yi, Wang, Li-Ya, Ding, Fan, Hu, Wenbiao, Soares Magalhaes, Ricardo J., Sun, Hai-Long, Liu, Yun-Xi, Liu, Qi-Yong, Huang, Liu-Yu, Clements, Archie C.A., Li, Shen-Long, & Li, Cheng-Yi (2013) Scrub typhus in mainland China, 2006–2012 : the need for targeted public health interventions. PLoS Neglected Tropical Diseases, 7(12), e2493.

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Abstract

Scrub typhus is a vector-borne disease carried by the chigger mite. The aetiological agent is the rickettsia Orientia tsutsugamushi, which is endemic to several countries in the Asia-Pacific region, including China [1]. It is also a travel-associated disease [2] and of great importance among military personnel [3], [4]. During the Second World War, scrub typhus was associated with a higher case fatality ratio than any other infectious disease in the China-Burma-India theatre of operations 1,3. Clinical presentation in patients varies from asymptomatic to life-threatening disease [5], including acute hearing loss and multiple organ failure [6], [7]. To date, there is still no effective and reliable human vaccine against scrub typhus and no point-of-care diagnostics available [1].

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ID Code: 67142
Item Type: Journal Article
Refereed: Yes
DOI: 10.1371/journal.pntd.0002493
ISSN: 1935-2735
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Zhang et al.
Copyright Statement: This is an open-access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium,
provided the original author and source are credited.
Deposited On: 12 Feb 2014 23:10
Last Modified: 14 Feb 2014 01:33

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