Deep dermal burn injury results in scarless wound healing in the ovine fetus
Fraser, John F., Cuttle, Leila, Kempf, Margit, Phillips, Gael E, O'Rourke, Peter K, Choo, Kelvin, Hayes, Mark T, & Kimble, Roy M (2005) Deep dermal burn injury results in scarless wound healing in the ovine fetus. Wound Repair and Regeneration, 13(2), pp. 189-197.
Early to mid-term fetuses heal cutaneous incisional wounds without scars; however, fetal response to burn injury has not been ascertained. We present a fetal model of thermal injury and subsequent analysis of fetal and lamb response to burn injury. A reproducible deep dermal burn injury was created in the fetus by application of water at 66 degrees C for 7 seconds, and at 82 degrees C for 10 seconds to the lamb. Macroscopically, the area of fetal scald was undetectable from day 7 post injury, while all lamb scalds were readily identified and eventually healed with scarring. Using a five-point histopathology scoring system for alteration in tissue morphology, differences were detected between control and scalded skin at all stages in lamb postburn, but no difference was detected in the fetal model after day 7. There were also large differences in content of alpha-smooth muscle actin and transforming growth factor-beta1 between control and scalded lamb and these differences were statistically significant at day 14 (P < 0.01). This novel model of fetal and lamb response to deep dermal injury indicates that the fetus heals a deep burn injury in a scarless fashion. Further elucidation of this specific fetal process of burn injury repair may lead to improved outcome for patients with burn injury.
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|Item Type:||Journal Article|
|Additional Information:||Fraser, John F
Phillips, Gael E
O'Rourke, Peter K
Hayes, Mark T
Kimble, Roy M
Wound Repair Regen. 2005 Mar-Apr;13(2):189-97.
|Keywords:||Actins/biosynthesis, Animals, Burns/metabolism/*physiopathology, Cicatrix/*physiopathology, Dermis/injuries/*physiopathology, Fetus, Models, Animal, Sheep, Transforming Growth Factor beta/metabolism, Transforming Growth Factor beta1, Wound Healing/*physiology|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright # 2005 by the Wound Healing Society|
|Deposited On:||26 Feb 2014 23:02|
|Last Modified:||25 Mar 2014 06:23|
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