The poor penetration of topical burn agent through burn eschar on a porcine burn model [Letter to the Editor]

Wang, Xue-Qing, Hayes, Mark T., Kempf, Margit, Cuttle, Leila, Mill, Julie, & Kimble, Roy M. (2009) The poor penetration of topical burn agent through burn eschar on a porcine burn model [Letter to the Editor]. Burns, 35(6), pp. 901-902.

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We read with great interest the article entitled “Enhancing drugs absorption through third-degree burn wound eschar” by Manafi et al. [1]. The authors addressed the concern of poor penetration of topically applied anti-microbials through burn eschar and detailed the improvement of this penetration by penetration enhancers. Here, we would like to report the poor penetration of a topical agent into the viable deep dermal layer under burn eschar on a porcine burn model [2]. In burn treatment, a common practice is the topical application of either anti-microbial products or wound enhancing agents. While the activity of anti-microbial products is designed to fight against microbes on the wound surface but with the least toxicity to viable tissue, wound enhancing agents need to reach the viable tissue layer under the burn eschar. Many studies have reported the accelerated healing of superficial burn wounds and skin graft donor sites by the topical application of exogeneous growth factors [3]. It is well known that the efficacy of the penetration of a topical agent on intact skin mostly depends on the molecular size of the product [4] and [5]. While burn injury destroys this epidermal physiological barrier, the coagulated burn tissue layer on the burn wound surface makes it difficult for topical agents to reach viable tissue....

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4 citations in Scopus
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3 citations in Web of Science®

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ID Code: 67222
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Administration, Cutaneous, Animals, Blood Proteins/*pharmacokinetics, Burns/*metabolism, Debridement, Disease Models, Animal, Female, Sus scrofa, alpha-2-HS-Glycoprotein
DOI: 10.1016/j.burns.2008.08.022
ISSN: 1879-1409
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2009 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in Burns. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Burns, [VOL 35, ISSUE 6, (2009)] DOI: 10.1016/j.burns.2008.08.022
Deposited On: 26 Feb 2014 23:13
Last Modified: 25 Mar 2014 04:44

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