Fetuin-A : a major fetal serum protein that promotes "wound closure" and scarless healing [Letter to the Editor]

Wang, Xue-Qing, Hayes, Mark T., Kempf, Margit, Fraser, John F., Liu, Pei-Yun, Cuttle, Leila, Friend, Lexie R. Robyn, Rothnagel, Joseph A., Saunders, Nicholas A., & Kimble, Roy M. (2008) Fetuin-A : a major fetal serum protein that promotes "wound closure" and scarless healing [Letter to the Editor]. Journal of Investigative Dermatology, 128(3), pp. 753-757.

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Burn-wound healing is a dynamic, interactive process involving a number of cellular and molecular events and is characterized by inflammation, granulation tissue formation, re-epithelialization, and tissue remodeling (Greenhalgh, 2002; Linares, 2002). Unlike incisional-wound healing, it also requires extensive re-epithelialization due to a predominant horizontal loss of tissue and often heals with abnormal scarring when burns involve deep dermis. The early mammalian fetus has the remarkable ability to regenerate normal epidermis and dermis and to heal dermal incisional wounds with no signs of scarring. Extensive research has indicated that scarless healing appears to be intrinsic to fetal skin (McCallion and Ferguson, 1996; Ferguson and O’Kane, 2004). Previously, we reported a fetal burn model, in which 80-day-old ovine fetuses (gestation¼ 145–153 days) healed deep dermal partial thickness burns without scars, whereas postnatal lambs healed equal depth burns with significant scarring (Cuttle et al., 2005; Fraser et al., 2005). This burn model provided early evidence that fetal skin has the capacity to repair and restore dermal horizontal loss, not just vertical injuries.

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ID Code: 67223
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Animals, Blood Proteins/*physiology, Burns/pathology/*physiopathology, Cells, Cultured, Cicatrix/pathology/*physiopathology, Fetus/physiology, Humans, Keratinocytes/pathology/physiology, Sheep, Wound Healing/*physiology, alpha-2-HS-Glycoprotein
DOI: 10.1038/sj.jid.5701119
ISSN: 1523-1747
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 Society for Investigative Dermatology
Deposited On: 26 Feb 2014 23:22
Last Modified: 25 Mar 2014 02:36

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