Mycobacterium abscessus isolated from municipal water : a potential source of human infection

Thomson, Rachel, Tolson, Carla, Sidjabat, Hanna, Huygens, Flavia, & Hargreaves, Megan (2013) Mycobacterium abscessus isolated from municipal water : a potential source of human infection. BMC Infectious Diseases, 13(241).

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Abstract

Background

Mycobacterium abscessus is a rapidly growing mycobacterium responsible for progressive pulmonary disease, soft tissue and wound infections. The incidence of disease due to M. abscessus has been increasing in Queensland. In a study of Brisbane drinking water, M. abscessus was isolated from ten different locations.

The aim of this study was to compare genotypically the M. abscessus isolates obtained from water to those obtained from human clinical specimens.

Methods

Between 2007 and 2009, eleven isolates confirmed as M. abscessus were recovered from potable water, one strain was isolated from a rainwater tank and another from a swimming pool and two from domestic taps. Seventy-four clinical isolates referred during the same time period were available for comparison using rep-PCR strain typing (Diversilab).

Results

The drinking water isolates formed two clusters with ≥97% genetic similarity (Water patterns 1 and 2). The tankwater isolate (WP4), one municipal water isolate (WP3) and the pool isolate (WP5) were distinctly different. Patient isolates formed clusters with all of the water isolates except for WP3. Further patient isolates were unrelated to the water isolates.

Conclusion

The high degree of similarity between strains of M. abscessus from potable water and strains causing infection in humans from the same geographical area, strengthens the possibility that drinking water may be the source of infection in these patients.

Impact and interest:

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ID Code: 67246
Item Type: Journal Article
Refereed: Yes
Keywords: M. absecessus, water, source, infection
DOI: 10.1186/1471-2334-13-241
ISSN: 1471-2334
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Infectious Agents (060502)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Thomson et al.; licensee BioMed Central Ltd.
Copyright Statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Deposited On: 12 Feb 2014 23:56
Last Modified: 01 May 2014 02:38

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