Recent advances in the design of artificial corneas

Griffith, May & Harkin, Damien G. (2014) Recent advances in the design of artificial corneas. Current Opinion in Ophthalmology, 25(3), pp. 240-247.

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Purpose of review: Artificial corneas are being developed to meet a shortage of donor corneas as well as to address cases where allografting is contraindicated. A range of artificial corneas has been developed. Here we review several newer designs and especially those inspired by naturally occurring biomaterials found with the human body and elsewhere.

Recent findings: Recent trends in the development of artificial corneas indicate a move towards the use of materials derived from native sources including decellularized corneal tissue and tissue substitutes synthesized by corneal cells in vitro when grown either on their own, or in conjunction with novel protein-based scaffolds. Biologically inspired materials are also being considered for implantation on their own with the view to promoting endogenous corneal tissue.

Summary: More recent attempts at making artificial corneas have taken a more nature-based or nature-inspired approach. Several will in the near future be likely to be available clinically.

Impact and interest:

10 citations in Scopus
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8 citations in Web of Science®

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17 since deposited on 16 Feb 2014
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ID Code: 67415
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Cornea, Tissue engineering, Artificial cornea, Regenerative medicine, Biomaterials
DOI: 10.1097/ICU.0000000000000049
ISSN: 1040-8738
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400) > Regenerative Medicine (incl. Stem Cells and Tissue Engineering) (100404)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Ophthalmology (111301)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins
Copyright Statement: This is a non-final version of an article published in final form in Current Opinion in Ophthalmology, 25(3):240-247, May 2014
Deposited On: 16 Feb 2014 22:28
Last Modified: 02 Jun 2015 18:48

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