Observation of solution-induced corneal staining with fluorescein, rose bengal and lissamine green

Maldonado-Codina, Carole, Read, Michael L., Efron, Nathan, Dobson, Curtis B., & Morgan, Philip B. (2013) Observation of solution-induced corneal staining with fluorescein, rose bengal and lissamine green. Contact Lens and Anterior Eye, 36(5), pp. 267-270.

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Ever since sodium fluorescein (‘fluorescein’ [FL]) was first used to investigate the ocular surface over a century ago, the term ‘staining’ has been taken to mean the presence of ocular surface fluorescence [1]. This term has not been necessarily taken to infer any particular mechanism of causation, and indeed, can be attributed to a variety of possible aetiologies [2].

In recent times, there has been considerable interest in a form of ocular surface fluorescence seen in association with the use of certain combinations of soft contact lenses and multipurpose solutions. The first clinical account of this phenomenon was reported by Jones et al. [3], which was followed by a more formal investigation by the same author in 2002 [4]. Jones et al described this appearance as a ‘classic solution-based toxicity reaction’. Subsequently, this appearance has come to be known as ‘solution-induced corneal staining’ or more recently by the acronym ‘SICS’ [5].

The term SICS is potentially problematic in that from a cell biology point of view, there is an inference that ‘staining’ means the entry of a dye into corneal epithelial cells. Morgan and Maldonado-Codina [2] noted there was no foundation of solid scientific literature underpinning our understanding of the true basic causative mechanisms of this phenomenon; since that time, further work has been published in this field [6] and [7] but questions still remain about the precise aetiology of this phenomenon...

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ID Code: 67436
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Solution-induced corneal staining; SICS; Fluorescein; Rose bengal; Lissamine green
DOI: 10.1016/j.clae.2013.02.011
ISSN: 1367-0484
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Deposited On: 17 Feb 2014 22:44
Last Modified: 18 Feb 2014 23:25

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