Strong and bioactive tri-calcium phosphate scaffolds with tube-like macropores

Zheng, Wei, Liu, Gang, Yan, Cheng, Xiao, Yin, & Miao, Xigeng (2014) Strong and bioactive tri-calcium phosphate scaffolds with tube-like macropores. Journal of Biomimetics, Biomaterials, and Tissue Engineering, 19, pp. 65-75.

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Abstract

Calcium phosphate ceramic scaffolds have been widely investigated for bone tissue engineering due to their excellent biocompatibility and biodegradation. Unfortunately, they have the shortcoming of low mechanical properties. In order to provide strong, bioactive, and biodegradable scaffolds, a new approach of infiltrating the macro-tube ABS (acrylontrile butadiene styrene) templates with a hydroxyapatite/bioactive glass mixed slurry was developed to fabricate porous Si-doped TCP (tri-calcium phosphate) scaffolds. The porous Si-doped TCP ceramics with a high porosity (~65%) and with interconnected macrotubes (~0.8mm in diameter) and micropores (5-100 m) had a high compressive strength (up to 14.68+0.2MPa), which was comparable to that of a trabecular bone and was much higher than those of pure TCP scaffolds. Additional cell attachment study and MTT cytotoxicity assay proved the bioactivity and biocompatibility of the new scaffolds. Thus a potential bioceramic material and a new approach to make the potential scaffolds were developed for bone tissue engineering.

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ID Code: 67530
Item Type: Journal Article
Refereed: Yes
Keywords: Tri-calcium phosphate, Scaffold, Compressive strength, Bioactivity
DOI: 10.4028/www.scientific.net/JBBTE.19.65
ISSN: 1662-100X
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2014 Trans Tech Publications, Switzerland
Deposited On: 26 Mar 2014 23:54
Last Modified: 13 Sep 2016 21:01

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