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Preparation and characterization of interpenetrating phased TCP/HA/PLGA composites

Miao, Xigeng, Lim, W-K., Huang, Xiao, & Chen, Y. (2005) Preparation and characterization of interpenetrating phased TCP/HA/PLGA composites. Materials Letters, 59(29-30), pp. 4000-4005.

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Abstract

The purpose of this study was to fabricate composites consisting of three interpenetrating networks: tricalcium phosphate (TCP), hydroxyapatite (HA), and poly(DL-lactide-co-glycolide) (PLGA). The porous TCP network was first produced by coating a polyurethane (PU) foam with hydrolysable alpha-TCP slurry. The HA network was derived from a calcium phosphate cement (CPC) filled in the porous TCP network. The remaining open pore network in the HA/TCP composite was further infiltrated with a PLGA network. The three sets of spatially continuous networks would have different biodegradation rates and thus bone tissue would grow towards the fastest biodegrading network while the remaining networks still maintaining their geometrical shape and carrying the physiological load for the tissue ingrowth.

Impact and interest:

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32 citations in Web of Science®

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ID Code: 6758
Item Type: Journal Article
Keywords: Interpenetrating composite, Calcium phosphate cement, Tricalcium phosphate, Poly(DL, lactide, co, glycolide)
DOI: 10.1016/j.matlet.2005.07.062
ISSN: 0167-577X
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MATERIALS ENGINEERING (091200) > Composite and Hybrid Materials (091202)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MATERIALS ENGINEERING (091200) > Ceramics (091201)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2005 Elsevier
Copyright Statement: Reproduced in accordance with the copyright policy of the publisher.
Deposited On: 30 Mar 2007
Last Modified: 29 Feb 2012 23:28

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