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Improvement in survival time and quality of life for patients with unresectable pancreatic cancer with weight stabilisation

Davidson, Wendy L., Ash, Susan, Capra, Sandra, & Bauer, Judith D. (2004) Improvement in survival time and quality of life for patients with unresectable pancreatic cancer with weight stabilisation. Clinical Nutrition, 23(2), pp. 239-247.

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Abstract

Background & aims: Cancer-induced weight loss is associated with poor outcomes and is common in pancreatic cancer. The aims were to determine whether stabilising weight loss for patients with unresectable pancreatic cancer was associated with improved survival and quality of life (QoL) and to identify determinants of weight stabilisation.

Methods: A post hoc analysis was performed using data from 107 patients in a multicentre trial. Patients were categorised as weight losing (>1 kg lost) or weight stable (1 kg lost) after an 8 week nutrition intervention period. Group survival duration (Kaplan Meier) and QoL (EORTC QLQ-C30) were compared. Predictors of weight stability were determined using logistic regression analysis.

Results: Patients with weight stabilisation survived longer from baseline (log rank test 5.53, P=0.019). They also reported higher QoL scores (P=0.037) and a greater mean energy intake (P<0.001) at Week 8 than those who continued to lose weight. The absence of nausea and vomiting (OR 6.5, P=0.010) and female gender (OR 5.2, P=0.020) were independent determinants of weight stabilisation.

Conclusions: Weight stabilisation over an 8 week period in weight-losing patients with unresectable pancreatic cancer was associated with improved survival duration and QoL.

Impact and interest:

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ID Code: 6771
Item Type: Journal Article
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details: s.ash@qut.edu.au
Keywords: nutrition, pancreatic neoplasms, cachexia, weight loss, quality of life, survival
DOI: 10.1016/j.clnu.2003.07.001
ISSN: 0261-5614
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Oncology and Carcinogenesis not elsewhere classified (111299)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NUTRITION AND DIETETICS (111100) > Nutrition and Dietetics not elsewhere classified (111199)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 Elsevier
Deposited On: 29 Mar 2007
Last Modified: 29 Feb 2012 23:31

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