Prognostic impact of vascular and lymphovascular invasion in early lung cancer

Al-Alao, Bassel S., Gately, Kathy, Nicholson, Siobhan, McGovern, Eilis, Young, Vincent K., & O'Byrne, Kenneth J. (2014) Prognostic impact of vascular and lymphovascular invasion in early lung cancer. Asian Cardiovascular and Thoracic Annals, 22(1), pp. 55-64.

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Abstract

Background

The prognostic significance of vascular and lymphatic invasion in non-small-cell lung cancer is under continuous debate. We analyzed the effect of tumor aggressiveness (lymphatic and/or vessel invasion) on survival and relapse in stage I and II non-small-cell lung cancer.

Methods

We retrospectively analyzed prospectively collected data of 457 patients with stage I and II non-small-cell lung cancer from 1998 to 2008. Specimens were analyzed for intratumoral vascular invasion and lymphovascular space invasion. Overall survival and disease-free survival were estimated using the Kaplan-Meier method, and differences were determined by the logrank test. Cox regression analysis was performed to identify independent risk factors. Results: The incidence of intratumoral vascular invasion was 23.4%, and this correlated significantly with grade of differentiation, visceral pleural involvement, lymphovascular space invasion, and N status. The incidence of lymphovascular space invasion was 5.5%, and this correlated significantly with grade of differentiation, lymph nodes involved, and intratumoral vascular invasion. On multivariate analyses, intratumoral vascular invasion proved to be an significant independent risk factor for overall survival but not for disease-free survival. Lymphovascular space invasion was associated significantly with early tumor recurrence but not with overall survival. Conclusions: Vascular and lymphatic invasion can serve as independent prognostic factors in completely resected nonsmall- cell lung cancer. Intratumoral vascular invasion and lymphovascular space invasion in early stage non-small-cell lung cancer are important factors in overall survival and early tumor recurrence. Further large scale studies with more recent patient cohorts and refined histological techniques are warranted.

Impact and interest:

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ID Code: 67763
Item Type: Journal Article
Refereed: Yes
Keywords: Carcinoma, Lung neoplasms, Neoplasm invasiveness, non-small-cell lung, Prognosis, Survival rate
DOI: 10.1177/0218492313478431
ISSN: 0218-4923
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 26 Feb 2014 01:40
Last Modified: 12 Mar 2014 05:36

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