The association of early life supplemental nutrition with lean body mass and grip strength in adulthood : evidence from APCAPS

Kulkarni, Bharati, Kuper, Hannah, Radhakrishna, K. V., Hills, Andrew P., Byrne, Nuala M., Taylor, Amy, Sullivan, Ruth, Bowen, Liza, Wells, Jonathan C., Ben-Shlomo, Yoav, Davey Smith, George, Ebrahim, Shah, & Kinra, Sanjay (2014) The association of early life supplemental nutrition with lean body mass and grip strength in adulthood : evidence from APCAPS. American Journal of Epidemiology, 179(6), pp. 700-709.

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Abstract

In the present study, we examined the associations of early nutrition with adult lean body mass (LBM) and muscle strength in a birth cohort that was established to assess the long-term impact of a nutrition program. Participants (n = 1,446, 32% female) were born near Hyderabad, India, in 29 villages from 1987 to 1990, during which time only intervention villages (n = 15) had a government program that offered balanced protein-calorie supplementation to pregnant women and children. Participants’ LBM and appendicular skeletal muscle mass were measured using dual energy x-ray absorptiometry; grip strength and information on lifestyle indicators, including diet and physical activity level, were also obtained. Ages (mean = 20.3 years) and body mass indexes (weight (kg)/height (m)2; mean = 19.5) of participants in 2 groups were similar. Current dietary energy intake was higher in the intervention group. Unadjusted LBM and grip strength were similar in 2 groups. After adjustment for potential confounders, the intervention group had lower LBM (β = −0.75; P = 0.03), appendicular skeletal muscle mass, and grip strength than did controls, but these differences were small in magnitude (<0.1 standard deviation). Multivariable regression analyses showed that current socioeconomic position, energy intake, and physical activity level had a positive association with adult LBM and muscle strength. This study could not detect a “programming” effect of early nutrition supplementation on adult LBM and muscle strength.

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ID Code: 67788
Item Type: Journal Article
Refereed: Yes
Keywords: Body composition, Nutrition supplementation, Lean body mass, Muscle mass, Muscle strength, Developmental origins of adult health and disease, Indian
DOI: 10.1093/aje/kwt332
ISSN: 1476-6256
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NUTRITION AND DIETETICS (111100) > Public Nutrition Intervention (111104)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Copyright Owner: Copyright 2014 The Authors
Copyright Statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited
Deposited On: 24 Feb 2014 23:04
Last Modified: 11 Sep 2014 02:07

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