A randomized controlled trial of a 10 percent CPP-ACP cream to reduce mutans streptococci colonization

Pukallus, Margaret L., Plonka, Kathryn A., Holcombe, Trevor F., Barnett, Adrian G., Walsh, Laurence J., & Seow, W. Kim (2013) A randomized controlled trial of a 10 percent CPP-ACP cream to reduce mutans streptococci colonization. Pediatric Dentistry, 35(7), pp. 550-555.

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The purpose of this study was to investigate the effectiveness of a 10 percent casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) cream to reduce mutans streptococci (MS) colonization and prevent early childhood caries.


The cohort was randomized at mean age of 11 days old to receive once-daily CPP-ACP cream (n=102) or no product (comparison group; n=89) from the time of first tooth eruption. All mothers were contacted by telephone at six, 12, and 18 months and advised to brush their children's teeth twice daily with low-dose fluoride toothpaste. At 24 months, all children were examined at a community clinic.


At 24 months old, one out of 65 (2 percent) children in the CPP-ACP group had caries vs. four out of 58 (seven percent) in the comparison group (difference not statistically significant). There were fewer MS-positive children in the CPP-ACP group (26 percent) vs. the comparison group (47 percent; P=.02). A dose-response effect of CPP-ACP usage on MS was observed, where MS was present in eight percent of regular CPP-ACP users, 28 percent of irregular users, and 47 percent of non-users (P<.02).


CPP-ACP reduced the percentages of mutans streptococci-positive 24-month-old children, although it did not reduce caries prevalence.

Impact and interest:

5 citations in Scopus
5 citations in Web of Science®
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ID Code: 67858
Item Type: Journal Article
Refereed: Yes
ISSN: 0164-1263
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > DENTISTRY (110500)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 American Academy of Pediatric Dentistry
Deposited On: 27 Feb 2014 01:12
Last Modified: 20 Jul 2017 21:01

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