Hydrogels containing silver nanoparticles for burn wounds show antimicrobial activity without cytotoxicity

Boonkaew, Benjawan, Suwanpreuksa, Pimpa, Cuttle, Leila, Barber, Philip Martin, & Supaphol, Pitt (2014) Hydrogels containing silver nanoparticles for burn wounds show antimicrobial activity without cytotoxicity. Journal of Applied Polymer Science, 131(9), p. 40215.

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This research introduces a novel dressing for burn wounds, containing silver nanoparticles in hydrogels for infected burn care. The 2-acrylamido-2-methylpropane sulfonic acid sodium salt hydrogels containing silver nanoparticles have been prepared via ultraviolet radiation. The formation of silver nanoparticles was monitored by surface plasmon bands and transmission electron microscopy. The concentration of silver nitrate loaded in the solutions slightly affected the physical properties and mechanical properties of the neat hydrogel. An indirect cytotoxicity study found that none of the hydrogels were toxic to tested cell lines. The measurement of cumulative release of silver indicated that 70%–82% of silver was released within 72 hr. The antibacterial activities of the hydrogels against common burn pathogens were studied and the results showed that 5 mM silver hydrogel had the greatest inhibitory activity. The results support its use as a potential burn wound dressing.

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7 citations in Scopus
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3 citations in Web of Science®

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ID Code: 67880
Item Type: Journal Article
Refereed: Yes
Keywords: Hydrogels; nanoparticles; antimicrobial activity; swelling; irradiation; hydrophilic polymers
DOI: 10.1002/app.40215
ISSN: 0021-8995
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 27 Feb 2014 04:47
Last Modified: 14 Mar 2014 03:43

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