Novel porous hydroxyapatite prepared by combing H2O2 foaming with PU sponge and modified with PLGA and bioactive glass

Huang, Xiao & Miao, Xigeng (2007) Novel porous hydroxyapatite prepared by combing H2O2 foaming with PU sponge and modified with PLGA and bioactive glass. Journal of Biomaterials Applications, 21(4), pp. 351-374.


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Porous hydroxyapatite (HA) scaffolds have been intensively studied and developed for bone tissue engineering, but their mechanical properties remain to be improved. This study was to prepare HA-based composite scaffolds that had a unique macroporous structure and special struts of a polymer/ ceramic interpenetrating composite and a bioactive coating. A novel combination of a polyurethane (PU) foam method and a hydrogen peroxide (H2O2) foaming method was used to fabricate the macroporous HA scaffolds. Micropores were present in the resulting porous HA ceramics after the unusual sintering of a common calcium phosphate cement and were infiltrated with the poly(D,L-lactic-co-glycolic acid) (PLGA) polymer. The internal surfaces of the macropores were further coated with a PLGA-bioactive glass composite coating. The porous composite scaffolds were characterized in terms of microstructure, mechanical properties and bioactivity. It was found that the HA scaffolds fabricated by the combined method showed high porosities of 61%-65% and proper macropore sizes of 200-600■m. The PLGA infiltration improved the compressive strengths of the scaffolds from 1.5-1.8MPa to 4.0-5.8MPa. Furthermore, the bioactive glass-PLGA coating rendered a good bioactivity to the composites, evidenced by the formation of an apatite layer on the sample surfaces immersed in the simulated body fluid (SBF) for 5 days. The porous HA-based composites obtained from this study had suitable porous structures, proper mechanical properties, and a high bioactivity, and thus could find potential application as scaffolds for bone tissue engineering.

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ID Code: 6792
Item Type: Journal Article
Refereed: Yes
Keywords: Hydroxyapatite, Porosity, Compressive strength, Bioactive glass, Poly(lactic, co, glycolic acid)
DOI: 10.1177/0885328206063905
ISSN: 1530-8022
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 Sage Publications
Copyright Statement: The final, definitive version of this article has been published in the Journal of Biomaterials Applications 21(4):pp. 351-374. © <SAGE Publications Ltd or Society/Proprietor, Year> by SAGE Publications Ltd
Deposited On: 29 Mar 2007 00:00
Last Modified: 29 Feb 2012 13:22

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