Porous calcium phosphate ceramics modified with PLGA-bioactive glass
Miao, Xigeng, Tan, L.-P., Tan, L.-S., & Huang, Xiao (2007) Porous calcium phosphate ceramics modified with PLGA-bioactive glass. Materials Science and Engineering C: Biomimetic Materials, Sensors and Systems, 27(2), pp. 274-279.
Porous calcium phosphate ceramics (mainly hydroxyapatite) with interconnected macropores (~ 1 mm) and micropores (~ 5 um) as well as high porosities (~ 80%) were prepared by firing polyurethane foams that were coated with calcium phosphate cement at 1200 degrees Celsius. In order to improve the mechanical properties such as compressive strength and compressive modulus and maintain the desirable bioactivity (i.e. the ability of apatite layer formation), the open micropores of the struts were infiltrated with poly(lactic-co-glycolic acid) (PLGA) to achieve an interpenetrating bioactive ceramic/ biodegradable polymer composite structure. The PLGA filled struts were further coated with a 58S bioactive glass (33wt%)-PLGA composite coating. The PLGA- bioactive glass modified porous calcium phosphate ceramics proved to be bioactive and exhibited compressive strengths up to 7.7 MPa and compressive moduli up to 3 GPa, which were comparable to those of natural spongy bones. The obtained complex porous bioactive/ biodegradable composites could be used as tissue engineering scaffolds for low-load bearing applications.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.
|Item Type:||Journal Article|
|Keywords:||hydroxyapatite, porosity, compressive strength, bioactive glass, poly(lactic, co, glycolic acid)|
|Subjects:||Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2007 Elsevier|
|Copyright Statement:||Reproduced in accordance with the copyright policy of the publisher.|
|Deposited On:||29 Mar 2007 00:00|
|Last Modified:||29 Feb 2012 13:25|
Repository Staff Only: item control page