Porous calcium phosphate ceramics modified with PLGA-bioactive glass

Miao, Xigeng, Tan, L.-P., Tan, L.-S., & Huang, Xiao (2007) Porous calcium phosphate ceramics modified with PLGA-bioactive glass. Materials Science and Engineering C: Biomimetic Materials, Sensors and Systems, 27(2), pp. 274-279.

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Porous calcium phosphate ceramics (mainly hydroxyapatite) with interconnected macropores (~ 1 mm) and micropores (~ 5 um) as well as high porosities (~ 80%) were prepared by firing polyurethane foams that were coated with calcium phosphate cement at 1200 degrees Celsius. In order to improve the mechanical properties such as compressive strength and compressive modulus and maintain the desirable bioactivity (i.e. the ability of apatite layer formation), the open micropores of the struts were infiltrated with poly(lactic-co-glycolic acid) (PLGA) to achieve an interpenetrating bioactive ceramic/ biodegradable polymer composite structure. The PLGA filled struts were further coated with a 58S bioactive glass (33wt%)-PLGA composite coating. The PLGA- bioactive glass modified porous calcium phosphate ceramics proved to be bioactive and exhibited compressive strengths up to 7.7 MPa and compressive moduli up to 3 GPa, which were comparable to those of natural spongy bones. The obtained complex porous bioactive/ biodegradable composites could be used as tissue engineering scaffolds for low-load bearing applications.

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52 citations in Web of Science®
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ID Code: 6796
Item Type: Journal Article
Refereed: Yes
Keywords: hydroxyapatite, porosity, compressive strength, bioactive glass, poly(lactic, co, glycolic acid)
DOI: 10.1016/j.msec.2006.05.008
ISSN: 0928-4931
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 Elsevier
Copyright Statement: Reproduced in accordance with the copyright policy of the publisher.
Deposited On: 29 Mar 2007 00:00
Last Modified: 29 Feb 2012 13:25

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