A recurrent network in the lateral amygdala : a mechanism for coincidence detection

Johnson, Luke R., Hou, Mian, Ponce-Alvarez, Adrian, Gribelyuk, Leo M., Alphs, Hannah H., Albert Jr, Ladislau, Brown, Bruce L., LeDoux, Joseph E., & Doyère, Valerie (2008) A recurrent network in the lateral amygdala : a mechanism for coincidence detection. Frontiers in Neural Circuits, 2.

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Synaptic changes at sensory inputs to the dorsal nucleus of the lateral amygdala (LAd) play a key role in the acquisition and storage of associative fear memory. However, neither the temporal nor spatial architecture of the LAd network response to sensory signals is understood. We developed a method for the elucidation of network behavior. Using this approach, temporally patterned polysynaptic recurrent network responses were found in LAd (intra-LA), both in vitro and in vivo, in response to activation of thalamic sensory afferents. Potentiation of thalamic afferents resulted in a depression of intra-LA synaptic activity, indicating a homeostatic response to changes in synaptic strength within the LAd network. Additionally, the latencies of thalamic afferent triggered recurrent network activity within the LAd overlap with known later occurring cortical afferent latencies. Thus, this recurrent network may facilitate temporal coincidence of sensory afferents within LAd during associative learning.

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ID Code: 67963
Item Type: Journal Article
Refereed: Yes
Keywords: Amygdala, Synapse, Reverberation, Autoassociative, Hopfield, LTD, Feedback, Polysynaptic, Fear Memory
DOI: 10.3389/neuro.04.003.2008
ISSN: 1662-5110
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
Copyright Owner: Copyright 2008 Johnson, Hou, Ponce-Alvarez, Gribelyuk, Alphs, Albert, Brown, LeDoux and Doyère
Copyright Statement: This document is protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.
Deposited On: 03 Mar 2014 01:07
Last Modified: 03 Mar 2014 01:07

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