Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdala

Radley, Jason J., Johnson, Luke R., Janssen, William G. M., Martino, Jeremiah, Lamprecht, Raphael, Hof, Patrick R., LeDoux, Joseph E., & Morrison, John H. (2006) Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdala. European Journal of Neuroscience, 24(3), pp. 876-884.

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Changes in dendritic spine number and shape are believed to reflect structural plasticity consequent to learning. Previous studies have strongly suggested that the dorsal subnucleus of the lateral amygdala is an important site of physiological plasticity in Pavlovian fear conditioning. In the present study, we examined the effect of auditory fear conditioning on dendritic spine numbers in the dorsal subnucleus of the lateral amygdala using an immunolabelling procedure to visualize the spine-associated protein spinophilin. Associatively conditioned rats that received paired tone and shock presentations had 35% more total spinophilin-immunoreactive spines than animals that had unpaired stimulation, consistent with the idea that changes in the number of dendritic spines occur during learning and account in part for memory.

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28 citations in Web of Science®

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ID Code: 67964
Item Type: Journal Article
Refereed: Yes
Keywords: Dendritic spine, Electron microscopy, Fear conditioning, Immunohistochemistry, Learning, Rat, Spinophilin
DOI: 10.1111/j.1460-9568.2006.04962.x
ISSN: 1460-9568
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
Deposited On: 03 Mar 2014 01:01
Last Modified: 03 Mar 2014 01:01

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