PTSD and traumatic stress : from gene to community and bench to bedside

Ursano, Robert J., Zhang, Lei, Li, He, Johnson, Luke, Carlton, Janis, Fullerton, Carol S., & Benedek, David M. (2009) PTSD and traumatic stress : from gene to community and bench to bedside. Brain Research, 1293, pp. 2-12.

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Individuals and communities are exposed to traumatic events, those that are accidents or naturally occurring and those that are intentional or human made. Although resilience is the expected response, for some, posttraumatic stress disorder may be the outcome. Brain models of PTSD require understanding the phenomenology of the disorder and the brain “break down” that occurs. Among several models, importantly, is the perspective that PTSD is a “forgetting” disorder. Other elements in the onset and triggers of PTSD can identify further models to examine at the bench. New studies of the 5-HT2A receptor, the glucocorticoid receptor, p11, mitochondrial genes and cannabinoids are bringing new perspectives to understanding brain function in PTSD. Effective treatments indicate areas for bench research on the mechanisms of the disorder.

Impact and interest:

14 citations in Scopus
11 citations in Web of Science®
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ID Code: 67971
Item Type: Journal Article
Refereed: Yes
Keywords: Stress, Posttraumatic stress disorder, PTSD, p11, Glucocorticoid, Cannabinoid, Serotonin receptor, Model, Disaster, Trauma, Traumatic stress
DOI: 10.1016/j.brainres.2009.03.030
ISSN: 0006-8993
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
Deposited On: 02 Mar 2014 23:17
Last Modified: 02 Mar 2014 23:17

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