Comparing skin biopsy with confocal microscopy : diagnostic yield of nerve fiber density

Quattrini, Christian, Tavakoli, Mitra, Kallinikos, Panagiotis A., Marshall, Alison L., Efron, Nathan, Boulton, Andrew J.M., & Malik, Rayaz A. (2010) Comparing skin biopsy with confocal microscopy : diagnostic yield of nerve fiber density. Diabetologia, 53(Supp 1), p. 1114.

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Abstract

Background and aims: The assessment of intra-epidermal nerve fiber density (IENFD) in skin biopsies and corneal nerve fiber density (CNFD) using corneal confocal microscopy (CCM) provides promising techniques to detect small nerve fiber damage in patients with peripheral neuropathy. To help define the clinical utility of each of these techniques in patients with diabetic neuropathy we have assessed sensitivity and specificity of IENFD and CNFD in predicting the following: 1) diabetic polyneuropathy (DPN); 2) risk of foot ulceration (RFU); 3) initial small fiber neuropathy (iSFN); 4) severe small fiber neuropathy (sSFN)...

Impact and interest:

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ID Code: 67979
Item Type: Journal Article
Refereed: Yes
Additional Information: Abstracts of the EASD, Stockholm 2010
DOI: 10.1007/s00125-010-1872-z
ISSN: 0012-186X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Deposited On: 03 Mar 2014 04:22
Last Modified: 10 Mar 2014 21:14

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