Olfactory glia enhance neonatal axon regeneration

Chehrehasa, Fatemeh, Windus, Louisa C.E., Ekberg, Jenny, Scott, Susan E., Amaya, Daniel, Mackay-Sim, Alan, & St John, James A. (2010) Olfactory glia enhance neonatal axon regeneration. Molecular and Cellular Neuroscience, 45(3), pp. 277-288.

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Olfactory ensheathing cells (OECs) migrate with olfactory axons that extend from the nasal epithelium into the olfactory bulb. Unlike other glia, OECs are thought to migrate ahead of growing axons instead of following defined axonal paths. However it remains unknown how the presence of axons and OECs influences the growth and migration of each other during regeneration. We have developed a regeneration model in neonatal mice to examine whether (i) the presence of OECs ahead of olfactory axons affects axonal growth and (ii) the presence of olfactory axons alters the distribution of OECs. We performed unilateral bulbectomy to ablate olfactory axons followed by methimazole administration to further delay neuronal growth. In this model OECs filled the cavity left by the bulbectomy before new axons extended into the cavity. We found that delaying axon growth increased the rate at which OECs filled the cavity. The axons subsequently grew over a significantly larger region and formed more distinct fascicles and glomeruli in comparison with growth in animals that had undergone only bulbectomy. In vitro, we confirmed (i) that olfactory axon growth was more rapid when OECs were more widely distributed than the axons and (ii) that OECs migrated faster in the absence of axons. These results demonstrate that the distribution of OECs can be increased by repressing by growth of olfactory axons and that olfactory axon growth is significantly enhanced if a permissive OEC environment is present prior to axon growth.

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ID Code: 68070
Item Type: Journal Article
Refereed: Yes
Keywords: Glia, olfactory bulb, methimazole, neuron, bulbectomy, fascicle
DOI: 10.1016/j.mcn.2010.07.002
ISSN: 1044-7431
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in Molecular and Cellular Neuroscience. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Molecular and Cellular Neuroscience, [VOL 45, ISSUE 3, (2010)] DOI: 10.1016/j.mcn.2010.07.002
Deposited On: 05 Mar 2014 22:39
Last Modified: 15 Sep 2016 18:01

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