Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse

Okutsu, Mitsuharu, Lira, Vitor A., Higashida, Kazuhiko, Peake, Jonathan, Higuchi, Mitsutoshi, & Suzuki, Katsuhiko (2014) Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse. Atherosclerosis, 232(2), pp. 414-419.

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Abstract

Chronic stress is an important risk factor for atherosclerosis, which is a chief process in the development of cardiovascular disease. Increased circulating levels of corticosterone have been documented in several animal models of chronic stress. However, it remains to be established whether corticosterone is sufficient to exacerbate atherosclerosis. To test this hypothesis, apolipoprotein E (ApoE)-deficient mice were fed a high-fat diet for 13 weeks with exposure to either corticosterone or vehicle in the drinking water (CORT and Con). Corticosterone treatment significantly increased atherosclerotic plaque area at the aortic root. Such exacerbation of atherosclerosis was accompanied by significantly lower levels of circulating white blood cells and serum interleukin-1β (IL-1β), and significantly elevated serum concentrations of total cholesterol, low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) and small dense low-density lipoprotein (sd-LDL) in CORT mice when compared to Con mice. These findings demonstrate that corticosterone is sufficient to exacerbate atherosclerosis in vivo despite its anti-inflammatory properties and that this marked pro-atherogenic phenotype is primarily associated with increased dyslipidaemia.

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ID Code: 68115
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/j.atherosclerosis.2013.11.076
ISSN: 0021-9150
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Elsevier Ireland Ltd.
Copyright Statement: NOTICE: this is the author’s version of a work that was accepted for publication in Atherosclerosis. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Atherosclerosis, [Volume 232, Issue 2, (February 2014)] DOI: 10.1016/j.atherosclerosis.2013.11.076
Deposited On: 07 Mar 2014 01:46
Last Modified: 05 Mar 2015 18:02

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