T helper cell cytokine profiles following endurance exercise

Kakanis, Michael, Peake, Jonathan, Brenu, Ekua, Simmonds, Michael, Gray, Bon, & Marshall-Gradisnik, Sonya (2014) T helper cell cytokine profiles following endurance exercise. Journal of Interferon & Cytokine Research, 34(9), pp. 699-706.

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Endurance exercise can cause immunosuppression and increase the risk of upper respiratory illness. The present study examined changes in the secretion of T helper (Th) cell cytokines after endurance exercise. Ten highly trained road cyclists [mean±SEM: age 24.2±1.7 years; height 1.82±0.02 m; body mass 73.8±2.0 kg; peak oxygen uptake 65.9±2.3 mL/(kg•min)] performed 2 h of cycling exercise at 90% of the second ventilatory threshold. Peripheral blood mononuclear cells were isolated and stimulated with phytohemagglutinin. Plasma cortisol concentrations and the concentration of Th1/Th2/Th17 cell cytokines were examined. Data were analyzed using both traditional statistics and magnitude-based inferences. Results revealed a significant decrease in plasma cortisol at 4–24 h postexercise compared with pre-exercise values. Qualitative analysis revealed postexercise changes in concentrations of plasma cortisol, IL-2, TNF, IL-4, IL-6, IL-10, and IL-17A compared with pre-exercise values. A Th1/Th2 shift was evident immediately postexercise. Furthermore, for multiple cytokines, including IL-2 and TNF (Th1), IL-6 and IL-10 (Th2), and IL-17 (Th17), no meaningful change in concentration occurred until more than 4 h postexercise, highlighting the duration of exercise-induced changes in immune function. These results demonstrate the importance of considering “clinically” significant versus statistically significant changes in immune cell function after exercise.

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ID Code: 68118
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Exercise, Immunology, Cytokines, Helper T-Lymphocytes
DOI: 10.1089/jir.2013.0031
ISSN: 1079-9907
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Exercise Physiology (110602)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Mary Ann Liebert, Inc. publishers
Copyright Statement: This is a copy of an article published in the Journal of Interferon & Cytokine Research © [2014] [copyright Mary Ann Liebert, Inc.]; Journal of Interferon & Cytokine Research is available online at: http://online.liebertpub.com.
Deposited On: 07 Mar 2014 02:02
Last Modified: 11 Sep 2014 00:33

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