Elucidating the host–pathogen interaction between human colorectal cells and invading Enterovirus 71 using transcriptomics profiling

Lui, Yan Long Edmund, Tan, Tuan Lin, Timms, Peter, Hafner, Louise M., Tan, Kian Hwa, & Tan, Eng Lee (2014) Elucidating the host–pathogen interaction between human colorectal cells and invading Enterovirus 71 using transcriptomics profiling. FEBS Open Bio, 4, pp. 426-431.

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Abstract

Enterovirus 71 (EV71) is one of the main etiological agents for Hand, Foot and Mouth Disease (HFMD) and has been shown to be associated with severe clinical manifestation. Currently, there is no antiviral therapeutic for the treatment of HFMD patients owing to a lack of understanding of EV71 pathogenesis. This study seeks to elucidate the transcriptomic changes that result from EV71 infection. Human whole genome microarray was employed to monitor changes in genomic profiles between infected and uninfected cells. The results reveal altered expression of human genes involved in critical pathways including the immune response and the stress response. Together, data from this study provide valuable insights into the host–pathogen interaction between human colorectal cells and EV71.

Impact and interest:

5 citations in Scopus
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6 citations in Web of Science®

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ID Code: 68179
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Enterovirus71, Transcriptomics, Microarray, mRNA profiling, Colorectal cells, Hand, Foot and Mouth Disease
DOI: 10.1016/j.fob.2014.04.005
ISSN: 2211-5463
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Virology (060506)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 The Authors
Copyright Statement: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/)
Deposited On: 10 Mar 2014 23:37
Last Modified: 10 Jul 2015 10:07

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