Immune regulation during chronic visceral leishmaniasis

Faleiro, Rebecca J., Kumar, Rajiv, Hafner, Louise M., & Engwerda, Christian R. (2014) Immune regulation during chronic visceral leishmaniasis. PLoS Neglected Tropical Diseases, 8(7), e2914.

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Visceral leishmaniasis is a chronic parasitic disease associated with severe immune dysfunction. Treatment options are limited to relatively toxic drugs and there is no vaccine for humans available. Hence, there is an urgent need to better understand immune responses following infection with Leishmania species by studying animal models of disease and clinical samples from patients. Here, we review recent discoveries in these areas and highlight shortcomings in our knowledge that need to be addressed if better treatment options are to be developed and effective vaccines designed.

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ID Code: 68187
Item Type: Journal Article
Refereed: Yes
Additional Information: This paper has been accepted for publication in PLOS Neglected Tropical Diseases on Sunday 9 March, 2014
Keywords: visceral leishmaniasis, immune regulation
DOI: 10.1371/journal.pntd.0002914
ISSN: 1935-2735
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Microbiology not elsewhere classified (060599)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 The Author(s)
Deposited On: 10 Mar 2014 23:34
Last Modified: 08 Dec 2014 05:26

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