Long term transmission of defective RNA viruses in humans and Aedes mosquitoes
Aaskov, John G., Buzacott, Katie, Thu, Hlaing Myat, Lowry, Kym S., & Holmes, Edward (2006) Long term transmission of defective RNA viruses in humans and Aedes mosquitoes. Science, 311(5758), pp. 236-238.
Abstract
In 2001, dengue virus type 1 (DENV-1) populations in humans and mosquitoes from Myanmar acquired a stop-codon mutation in the surface envelope (E) protein gene. Within a year, this stop-codon strain had spread to all individuals sampled. The presence of truncated E protein species within individual viral populations, along with a general relaxation in selective constraint, indicated that the stop-codon strain represents a defective lineage of DENV-1. We propose that such long-term transmission of defective RNA viruses in nature was achieved through complementation by coinfection of host cells with functional viruses.
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| ID Code: | 6820 |
|---|---|
| Item Type: | Journal Article |
| Additional Information: | For more information, please refer to the journal’s website (see hypertext link) or contact the author: j.aaskov@qut.edu.au |
| Keywords: | dengue viruses |
| DOI: | 10.1126/science.1115030 |
| ISSN: | 1095-9203 |
| Subjects: | Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Virology (060506) |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Science and Technology Current > Institutes > Institute of Health and Biomedical Innovation |
| Copyright Owner: | Copyright 2006 American Association for the Advancement of Science |
| Deposited On: | 30 Mar 2007 |
| Last Modified: | 29 Feb 2012 23:27 |
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