Long term transmission of defective RNA viruses in humans and Aedes mosquitoes

Aaskov, John G., Buzacott, Katie, Thu, Hlaing Myat, Lowry, Kym S., & Holmes, Edward (2006) Long term transmission of defective RNA viruses in humans and Aedes mosquitoes. Science, 311(5758), pp. 236-238.

View at publisher (open access)


In 2001, dengue virus type 1 (DENV-1) populations in humans and mosquitoes from Myanmar acquired a stop-codon mutation in the surface envelope (E) protein gene. Within a year, this stop-codon strain had spread to all individuals sampled. The presence of truncated E protein species within individual viral populations, along with a general relaxation in selective constraint, indicated that the stop-codon strain represents a defective lineage of DENV-1. We propose that such long-term transmission of defective RNA viruses in nature was achieved through complementation by coinfection of host cells with functional viruses.

Impact and interest:

136 citations in Scopus
Search Google Scholar™
132 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 6820
Item Type: Journal Article
Refereed: Yes
Additional Information: Articles free to read on journal website after if you register
Keywords: dengue viruses
DOI: 10.1126/science.1115030
ISSN: 1095-9203
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Virology (060506)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2006 American Association for the Advancement of Science
Deposited On: 30 Mar 2007 00:00
Last Modified: 02 Feb 2015 01:42

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page