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Long term transmission of defective RNA viruses in humans and Aedes mosquitoes

Aaskov, John G., Buzacott, Katie, Thu, Hlaing Myat, Lowry, Kym S., & Holmes, Edward (2006) Long term transmission of defective RNA viruses in humans and Aedes mosquitoes. Science, 311(5758), pp. 236-238.

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In 2001, dengue virus type 1 (DENV-1) populations in humans and mosquitoes from Myanmar acquired a stop-codon mutation in the surface envelope (E) protein gene. Within a year, this stop-codon strain had spread to all individuals sampled. The presence of truncated E protein species within individual viral populations, along with a general relaxation in selective constraint, indicated that the stop-codon strain represents a defective lineage of DENV-1. We propose that such long-term transmission of defective RNA viruses in nature was achieved through complementation by coinfection of host cells with functional viruses.

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102 citations in Web of Science®

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ID Code: 6820
Item Type: Journal Article
Additional Information: For more information, please refer to the journal’s website (see hypertext link) or contact the author: j.aaskov@qut.edu.au
Keywords: dengue viruses
DOI: 10.1126/science.1115030
ISSN: 1095-9203
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Virology (060506)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2006 American Association for the Advancement of Science
Deposited On: 30 Mar 2007
Last Modified: 29 Feb 2012 13:27

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