Long term transmission of defective RNA viruses in humans and Aedes mosquitoes
Aaskov, John G., Buzacott, Katie, Thu, Hlaing Myat, Lowry, Kym S., & Holmes, Edward (2006) Long term transmission of defective RNA viruses in humans and Aedes mosquitoes. Science, 311(5758), pp. 236-238.
In 2001, dengue virus type 1 (DENV-1) populations in humans and mosquitoes from Myanmar acquired a stop-codon mutation in the surface envelope (E) protein gene. Within a year, this stop-codon strain had spread to all individuals sampled. The presence of truncated E protein species within individual viral populations, along with a general relaxation in selective constraint, indicated that the stop-codon strain represents a defective lineage of DENV-1. We propose that such long-term transmission of defective RNA viruses in nature was achieved through complementation by coinfection of host cells with functional viruses.
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|Item Type:||Journal Article|
|Additional Information:||Articles free to read on journal website after if you register|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Virology (060506)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2006 American Association for the Advancement of Science|
|Deposited On:||30 Mar 2007|
|Last Modified:||02 Feb 2015 01:42|
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