Lineage extinction and replacement in dengue type 1 virus populations are due to stochastic events rather than to natural selection
Thu, Hlaing Myat, Lowry, Kym S., Jiang, Limin, Hlaing, Thaung, Holmes, Edward C., & Aaskov, John G. (2005) Lineage extinction and replacement in dengue type 1 virus populations are due to stochastic events rather than to natural selection. Virology, 336(2), pp. 163-172.
Between 1996 and 1998 two clades (B,C; genotype I) of dengue virus type 1 (DENV-1) appeared in Myanmar (Burma) that were new to that location. Between 1998 and 2000 a third clade (A; genotype III) of DENV-1, which had been circulating at that locality for at least twenty-five years, became extinct. These changes preceded the largest outbreak of dengue recorded in Myanmar, in 2001, in which more than 95% of viruses recovered from patients were DENV-1 but where the incidence of severe disease was much less than in previous years. Phylogenetic analyses of viral genomes indicated that the two new clades of DENV-1 did not arise from the, now extinct, clade A viruses nor was the extinction of this clade due to differences in the fitness of the viral populations. Since the extinction occurred during in an inter-epidemic period, we suggest that it was due to a stochastic event attributable to the low rate of virus transmission in this interval.
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|Item Type:||Journal Article|
|Additional Information:||For more information, please refer to the journal’s website (see hypertext link) or contact the author: email@example.com|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Virology (060506)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2005 Elsevier|
|Deposited On:||30 Mar 2007|
|Last Modified:||29 Feb 2012 23:13|
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