Lineage extinction and replacement in dengue type 1 virus populations are due to stochastic events rather than to natural selection
Thu, Hlaing Myat, Lowry, Kym S., Jiang, Limin, Hlaing, Thaung, Holmes, Edward C., & Aaskov, John G. (2005) Lineage extinction and replacement in dengue type 1 virus populations are due to stochastic events rather than to natural selection. Virology, 336(2), pp. 163-172.
Between 1996 and 1998 two clades (B,C; genotype I) of dengue virus type 1 (DENV-1) appeared in Myanmar (Burma) that were new to that location. Between 1998 and 2000 a third clade (A; genotype III) of DENV-1, which had been circulating at that locality for at least twenty-five years, became extinct. These changes preceded the largest outbreak of dengue recorded in Myanmar, in 2001, in which more than 95% of viruses recovered from patients were DENV-1 but where the incidence of severe disease was much less than in previous years. Phylogenetic analyses of viral genomes indicated that the two new clades of DENV-1 did not arise from the, now extinct, clade A viruses nor was the extinction of this clade due to differences in the fitness of the viral populations. Since the extinction occurred during in an inter-epidemic period, we suggest that it was due to a stochastic event attributable to the low rate of virus transmission in this interval.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Additional Information:||For more information, please refer to the journal’s website (see hypertext link) or contact the author: firstname.lastname@example.org|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Virology (060506)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2005 Elsevier|
|Deposited On:||30 Mar 2007 00:00|
|Last Modified:||28 Apr 2015 04:22|
Repository Staff Only: item control page