Sustained transmission of dengue virus type 1 in the Pacific due to repeated introductions of different Asian strains
A-Nuegoonpipat, Atchareeya, Berlioz-Arthaud, Alain, Chow, Vincent, Endy, Tim, Lowry, Kym S., Mai, Le Quynh, Ninh, Truong Uyen, Pyke, Alyssa, Reid, Mark, Reynes, Jean-Marc, Su-Yun, Se-Thoe, Thu, Hlaing Myat, Wong, Sook-San, Holmes, Edward, & Aaskov, John G. (2004) Sustained transmission of dengue virus type 1 in the Pacific due to repeated introductions of different Asian strains. Virology, 329(2), pp. 505-512.
Outbreaks of dengue due to dengue virus type 1 (DENV-1) occurred almost simultaneously in 2001 in Myanmar and at multiple sites almost 10,000 km away in the Pacific. Phylogenetic analyses of the E protein genes of DENV-1 strains recovered from Asia and the Pacific revealed three major viral genotypes (I, II, and III) with distinct clades within each. The majority of strains from the Pacific and Myanmar, and a number of other Asian strains fell into genotype I. Genotype II comprised a smaller set of Asian and Pacific strains, while genotype III contained viruses from diverse geographical localities. These analyses suggested that the continuing outbreak of dengue in the Pacific has been due to multiple, direct, introductions of dengue viruses from a variety of locations in Asia followed by local transmission. There was no evidence that the introduction of these viruses into the Pacific was associated with any adaptive changes in the E protein of the viruses.
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|Item Type:||Journal Article|
|Additional Information:||For more information, please refer to the journal’s website (see link) or contact the author. Author contact details: firstname.lastname@example.org|
|Keywords:||Dengue viruses, evolution, phylogeny, epidemiology, Asia and the Pacific|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Virology (060506)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2004 Elsevier|
|Deposited On:||30 Mar 2007|
|Last Modified:||29 Feb 2012 13:04|
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