Functional loss in early age-related maculopathy: the ischaemia postreceptoral hypothesis

Feigl, Beatrix, Brown, Brian, Lovie-Kitchin, Janette E., & Swann, Peter G. (2007) Functional loss in early age-related maculopathy: the ischaemia postreceptoral hypothesis. Eye, 21(-), pp. 689-696.

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We review proposed models and psychophysical and electrophysiological tests performed in many studies for early age-related maculopathy (ARM). We suggest that ischaemia is the trigger for impaired retinal pigment epithelium function causing imbalance of secretion of vascular growth factors, reduced disc degradation capability and reduced metabolic activity and possible inflammatory response. This results in increased depostion of cell debris, such as drusen and thickens Bruch's membrane causing even more ischaemia of the overlying neurosensory retina. The photoreceptors are more resistant to ischaemia given their proximity to the choroid. Furthermore, being 'upstream' from the inner retinal layers, they act as an oxygen sink depriving retinal layers further from the choroid. Postreceptoral cell layers and especially parts of the inner nuclear layer that are located in the watershed zone between two sources of blood supply are preferentially vulnerable to ischaemia. Based on psychophysical and electrophysiological findings we propose that most of the function impairmetn in early ARM starts postreceptorally.

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18 citations in Web of Science®
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ID Code: 6826
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details:
Keywords: age, related maculopathy, ischaemia, multifocal electroretinogram, multifocal ERG, VEGF
DOI: 10.1038/sj.eye.6702389
ISSN: 0950-222X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 Nature Publishing Group
Deposited On: 05 Jul 2007 00:00
Last Modified: 29 Feb 2012 13:23

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