Cone-and rod-mediated multifocal electroretinogram in early age-related maculopathy

Feigl, Beatrix, Brown, Brian, Lovie-Kitchin, Janette E., & Swann, Peter G. (2005) Cone-and rod-mediated multifocal electroretinogram in early age-related maculopathy. Eye, 19(4), pp. 431-441.

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Purpose. To investigate the cone- and rod-mediated multifocal electroretinograms (mfERG) in early age-related maculopathy (early ARM).

Methods and subjects. We investigated the cone and rod-mediated mfERG in 17 eyes of 17 subjects with early ARM and 16 eyes of 16 age-matched control subjects with normal fundi. All subjects had a visual acuity of 6/12 or better. We divided the ARM subjects into two groups based on drusen size and retinal pigment epithelium abnormalities - a less advanced (ARM1) and a more advanced (ARM2) group. The mfERG data were compared to templates derived from the control group. We analysed the mfERG results for the central and peripheral fields (CP method) and the superior and inferior fields (SI method).

Results. While the mean cone results showed no statistically significant difference between the groups, the rods showed significantly delayed responses in the ARM1 group for the CP and the SI methods, but not in the ARM2 group, although there was a trend of lower response amplitudes compared to the control group.

Conclusion. Our results show a functional impairment of the rods in early ARM subjects. As there is histopathological evidence showing earlier rod than cone impairment in early ARM, following the rod function with the mfERG might be helpful in diagnosis or for monitoring the progression of early ARM.

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32 citations in Web of Science®
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ID Code: 6827
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details:
Keywords: age, related maculopathy, cones, rods, multifocal electroretinogram, multifocal ERG
DOI: 10.1038/sj.eye.6701503
ISSN: 0950-222X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2005 Nature Publishing Group
Deposited On: 05 Jul 2007 00:00
Last Modified: 29 Feb 2012 13:15

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